Polygenic Risk Score Reports, Compared
Polygenic risk scores have gone mainstream, and the consumer genomics market has fragmented into subscription platforms, WGS-bundled reports, and a handful of one-time upload services. Here's a neutral side-by-side of the options people actually consider in 2026.
At a glance
You already have a supported raw DNA file or WGS VCF and want a focused, one-time polygenic risk score report with 71 scores for $29.99.
You want bundled WGS (Nucleus), ongoing coaching + supplement recs (SelfDecode), or an FDA-regulated brand (23andMe+).
Pricing
Public list prices. Genomisaur Health Reports are $20–$29.99 one-time.
| Option | Price | What it is |
|---|---|---|
| Genomisaur — Full Health Report | $29.99 one-time | 71 PRS + trait predictions from existing DNA |
| Nucleus Genomics | $399 + $39/yr | WGS-bundled PRS + hundreds of conditions |
| SelfDecode | ~$120/yr | Subscription with AI coaching + supplements |
| 23andMe+ Premium | $199 + $69/yr | Genotype kit + FDA-cleared health reports |
| Promethease | $12 per file | SNPedia variant lookup (not modern PRS) |
| Sequencing.com | Free upload; apps $5–$99 each | App marketplace, 300+ report apps |
Competitor prices are public list prices from each vendor's site as of 2026 and change often; confirm on the vendor's site before purchasing.
Feature comparison
Side-by-side on the things that actually change what the product does for you.
| Feature | Genomisaur | Consumer PRS market | Edge |
|---|---|---|---|
| Accepts 23andMe / AncestryDNA / MyHeritage | Yes | SelfDecode, 23andMe, Promethease, Sequencing.com: yes. Nucleus: no. | |
| Accepts WGS VCF from any provider | Yes — every report tier | Varies by service | |
| Payment model | One-time | Mostly subscription or kit+subscription | |
| Number of PRS | 71 across 14 categories | Nucleus ~20. SelfDecode dozens. 23andMe single-variant. | |
| Per-score methodology transparency | GWAS source + performance metrics on every card | Varies widely; often not disclosed | |
| Turnaround | ~20 min | Nucleus ~6 wk. 23andMe 3–5 wk. Others variable. | |
| Requires new kit | No | Nucleus + 23andMe: yes. Upload services: no. | |
| Cost over 3 years | $29.99 | Nucleus 477, SelfDecode 360, 23andMe+ 406 |
What each one does well
Genomisaur
- $29.99 one-time — cheapest polygenic risk score report in the market
- Largest PRS library in the upload category (71 scores, 14 categories)
- No subscription, no kit, no upsell — one report, yours to keep
- Every score cites its source GWAS and performance metrics
Consumer PRS market
- Nucleus: bundles WGS, best if you have no DNA data yet
- SelfDecode: richest ongoing experience with AI coaching + supplement recs
- 23andMe+: FDA-cleared reports and regulated brand
- Sequencing.com: broadest a-la-carte app marketplace
For most people with existing consumer DNA data, Genomisaur has the best price-to-coverage ratio in this market: 71 polygenic risk scores for $29.99, no subscription. If you have no DNA data yet, Nucleus Genomics is the cleanest one-stop WGS + PRS buy. If you want ongoing coaching and don't mind paying yearly, SelfDecode is the richer experience. Pick by what you actually need; we have tried to be straight about where each one is strong.
Frequently asked questions
What is a polygenic risk score, in one sentence?
A polygenic risk score sums the effects of many common genetic variants into a single number representing where a person sits on the population risk spectrum for a given trait or disease.
Which service has the most polygenic risk scores?
Of upload-friendly consumer services in 2026, Genomisaur publishes the most at 71 PRS across 14 categories. Nucleus and SelfDecode offer fewer (though Nucleus supplements its PRS with hundreds of single-gene condition reports).
Which is the cheapest?
Promethease at $12 is cheapest but is a single-SNP SNPedia lookup, not modern PRS. Among actual PRS reports, Genomisaur at $29.99 one-time is the cheapest.
Do any of these replace a doctor?
No. All consumer PRS reports — including Genomisaur — are informational. Discuss results with a qualified healthcare provider before making medical decisions.
Can I use more than one of these services?
Yes. A common stack is to upload an existing array file or WGS VCF to Genomisaur for the focused PRS report, then use other services for niche apps or clinical interpretation.
Informational, not diagnostic
Consumer genetic reports — ours, Consumer PRS market's, and others — are informational. Carrier and polygenic risk results should be discussed with a qualified healthcare provider or genetic counselor before making medical or reproductive decisions.